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Dual oxidase in mucosal immunity and host-microbe homeostasis

Title
Dual oxidase in mucosal immunity and host-microbe homeostasis
Authors
Bae Y.S.Choi M.K.Lee W.-J.
Ewha Authors
배윤수이원재최명권
SCOPUS Author ID
배윤수scopus
Issue Date
2010
Journal Title
Trends in Immunology
ISSN
1471-4906JCR Link
Citation
vol. 31, no. 7, pp. 278 - 287
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Mucosal epithelia are in direct contact with microbes, which range from beneficial symbionts to pathogens. Accordingly, hosts must have a conflicting strategy to combat pathogens efficiently while tolerating symbionts. Recent progress has revealed that dual oxidase (DUOX) plays a key role in mucosal immunity in organisms that range from flies to humans. Information from the genetic model of Drosophila has advanced our understanding of the regulatory mechanism of DUOX and its role in mucosal immunity. Further investigations of DUOX regulation in response to symbiotic or non-symbiotic bacteria and the in vivo consequences in host physiology will give a novel insight into the microbe-controlling system of the mucosa. © 2010 Elsevier Ltd.
DOI
10.1016/j.it.2010.05.003
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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