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Vascular endothelial growth factor, fms-like tyrosine kinase-1 (Flt-1) and soluble Flt-1 gene expressions in Korean pre-eclamptic placentas

Title
Vascular endothelial growth factor, fms-like tyrosine kinase-1 (Flt-1) and soluble Flt-1 gene expressions in Korean pre-eclamptic placentas
Authors
Park J.-S.Baik H.-W.Lee S.-K.Na W.-S.Song Y.-R.Yang Y.-S.Park M.-H.Hwang I.-T.Oh K.-Y.
Ewha Authors
박미혜
SCOPUS Author ID
박미혜scopus
Issue Date
2010
Journal Title
Journal of Obstetrics and Gynaecology Research
ISSN
1341-8076JCR Link
Citation
vol. 36, no. 4, pp. 726 - 732
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Aim: To assess the expressions of vascular endothelial growth factor (VEGF), fms-like tyrosine kinase-1 (Flt-1), and soluble Flt-1 (sFlt-1) genes in healthy normotensive and pre-eclamptic placentas of Korean women. Methods: We investigated 12 healthy normotensive pregnant women and 10 pre-eclamptic pregnant women at Eulji University Hospital. The obtained placental tissues were analyzed using reverse transcription polymerase chain reaction and real-time quantitative polymerase chain reaction. Results: The sFlt-1 messenger ribonucleic acid (mRNA) level was elevated 2.6 times more in pre-eclamptic placentas than in normal control placentas. However, the VEGF mRNA level of pre-eclamptic placentas was decreased. There was no difference in the Flt-1 mRNA level between control and pre-eclamptic placentas. Conclusions: Our study showed that expressions of genes relating to angiogenesis were altered in Korean pre-eclamptic placentas. These results suggest that the alteration in expressions of sFlt-1 and VEGF genes might be associated with the pathogenesis of pre-eclampsia. © 2010 Japan Society of Obstetrics and Gynecology.
DOI
10.1111/j.1447-0756.2010.01208.x
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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