Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박미혜 | * |
dc.date.accessioned | 2016-08-28T12:08:29Z | - |
dc.date.available | 2016-08-28T12:08:29Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 1341-8076 | * |
dc.identifier.other | OAK-6747 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220932 | - |
dc.description.abstract | Aim: To assess the expressions of vascular endothelial growth factor (VEGF), fms-like tyrosine kinase-1 (Flt-1), and soluble Flt-1 (sFlt-1) genes in healthy normotensive and pre-eclamptic placentas of Korean women. Methods: We investigated 12 healthy normotensive pregnant women and 10 pre-eclamptic pregnant women at Eulji University Hospital. The obtained placental tissues were analyzed using reverse transcription polymerase chain reaction and real-time quantitative polymerase chain reaction. Results: The sFlt-1 messenger ribonucleic acid (mRNA) level was elevated 2.6 times more in pre-eclamptic placentas than in normal control placentas. However, the VEGF mRNA level of pre-eclamptic placentas was decreased. There was no difference in the Flt-1 mRNA level between control and pre-eclamptic placentas. Conclusions: Our study showed that expressions of genes relating to angiogenesis were altered in Korean pre-eclamptic placentas. These results suggest that the alteration in expressions of sFlt-1 and VEGF genes might be associated with the pathogenesis of pre-eclampsia. © 2010 Japan Society of Obstetrics and Gynecology. | * |
dc.language | English | * |
dc.title | Vascular endothelial growth factor, fms-like tyrosine kinase-1 (Flt-1) and soluble Flt-1 gene expressions in Korean pre-eclamptic placentas | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 36 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 726 | * |
dc.relation.lastpage | 732 | * |
dc.relation.journaltitle | Journal of Obstetrics and Gynaecology Research | * |
dc.identifier.doi | 10.1111/j.1447-0756.2010.01208.x | * |
dc.identifier.wosid | WOS:000280199300002 | * |
dc.identifier.scopusid | 2-s2.0-77954914398 | * |
dc.author.google | Park J.-S. | * |
dc.author.google | Baik H.-W. | * |
dc.author.google | Lee S.-K. | * |
dc.author.google | Na W.-S. | * |
dc.author.google | Song Y.-R. | * |
dc.author.google | Yang Y.-S. | * |
dc.author.google | Park M.-H. | * |
dc.author.google | Hwang I.-T. | * |
dc.author.google | Oh K.-Y. | * |
dc.contributor.scopusid | 박미혜(57218662303;58492640400) | * |
dc.date.modifydate | 20240118164151 | * |