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Antidepressant-like effect of Salvia sclarea is explained by modulation of dopamine activities in rats
- Antidepressant-like effect of Salvia sclarea is explained by modulation of dopamine activities in rats
- Seol G.H.; Shim H.S.; Kim P.-J.; Moon H.K.; Lee K.H.; Shim I.; Suh S.H.; Min S.S.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Journal of Ethnopharmacology
- vol. 130, no. 1, pp. 187 - 190
- SCI; SCIE; SCOPUS
- Aim of the study: The purpose of the present study was to screen aromatic essential oils that have antidepressant effects to identify the regulatory mechanisms of selected essential oils. Materials and methods: The antidepressant effects of essential oils of Anthemis nobilis (chamomile), Salvia sclarea (clary sage; clary), Rosmarinus officinalis (rosemary), and Lavandula angustifolia (lavender) were assessed using a forced swim test (FST) in rats. Rats were treated with essential oils by intraperitoneal injection or inhalation. Serum levels of corticosterone were assessed by enzyme-linked immunosorbent assay (ELISA). Results: Among the essential oils tested, 5% (v/v) clary oil had the strongest anti-stressor effect in the FST. We further investigated the mechanism of clary oil antidepression by pretreatment with agonists or antagonists to serotonin (5-HT), dopamine (DA), adrenaline, and GABA receptors. The anti-stressor effect of clary oil was significantly blocked by pretreatment with buspirone (a 5-HT1A agonist), SCH-23390 (a D1 receptor antagonist) and haloperidol (a D2, D3, and D4 receptor antagonist). Conclusions: Our findings indicate that clary oil could be developed as a therapeutic agent for patients with depression and that the antidepressant-like effect of clary oil is closely associated with modulation of the DAnergic pathway. © 2010 Elsevier Ireland Ltd.
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