Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 서석효 | - |
dc.date.accessioned | 2016-08-28T12:08:27Z | - |
dc.date.available | 2016-08-28T12:08:27Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.other | OAK-6725 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220913 | - |
dc.description.abstract | Aim of the study: The purpose of the present study was to screen aromatic essential oils that have antidepressant effects to identify the regulatory mechanisms of selected essential oils. Materials and methods: The antidepressant effects of essential oils of Anthemis nobilis (chamomile), Salvia sclarea (clary sage; clary), Rosmarinus officinalis (rosemary), and Lavandula angustifolia (lavender) were assessed using a forced swim test (FST) in rats. Rats were treated with essential oils by intraperitoneal injection or inhalation. Serum levels of corticosterone were assessed by enzyme-linked immunosorbent assay (ELISA). Results: Among the essential oils tested, 5% (v/v) clary oil had the strongest anti-stressor effect in the FST. We further investigated the mechanism of clary oil antidepression by pretreatment with agonists or antagonists to serotonin (5-HT), dopamine (DA), adrenaline, and GABA receptors. The anti-stressor effect of clary oil was significantly blocked by pretreatment with buspirone (a 5-HT1A agonist), SCH-23390 (a D1 receptor antagonist) and haloperidol (a D2, D3, and D4 receptor antagonist). Conclusions: Our findings indicate that clary oil could be developed as a therapeutic agent for patients with depression and that the antidepressant-like effect of clary oil is closely associated with modulation of the DAnergic pathway. © 2010 Elsevier Ireland Ltd. | - |
dc.language | English | - |
dc.title | Antidepressant-like effect of Salvia sclarea is explained by modulation of dopamine activities in rats | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 130 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 187 | - |
dc.relation.lastpage | 190 | - |
dc.relation.journaltitle | Journal of Ethnopharmacology | - |
dc.identifier.doi | 10.1016/j.jep.2010.04.035 | - |
dc.identifier.wosid | WOS:000279886900030 | - |
dc.identifier.scopusid | 2-s2.0-77953807545 | - |
dc.author.google | Seol G.H. | - |
dc.author.google | Shim H.S. | - |
dc.author.google | Kim P.-J. | - |
dc.author.google | Moon H.K. | - |
dc.author.google | Lee K.H. | - |
dc.author.google | Shim I. | - |
dc.author.google | Suh S.H. | - |
dc.author.google | Min S.S. | - |
dc.contributor.scopusid | 서석효(55666113100) | - |
dc.date.modifydate | 20230901081001 | - |