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4-Hydroxy-2'-nitrodiphenyl ether analogues as novel tyrosinase inhibitors

Title
4-Hydroxy-2'-nitrodiphenyl ether analogues as novel tyrosinase inhibitors
Authors
Sapkota K.Lee E.Yang J.-H.Kwon Y.Choi J.Na Y.
Ewha Authors
권영주
SCOPUS Author ID
권영주scopus
Issue Date
2010
Journal Title
Bulletin of the Korean Chemical Society
ISSN
0253-2964JCR Link
Citation
vol. 31, no. 5, pp. 1319 - 1325
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Tyrosinase ubiquitously existing from microorganisms to animals and plants is known to be the most critical and rate limiting enzyme during melanin biosynthesis. In order to develop new tyrosinase inhibitor we have synthesized 14 diphenyl ether compounds possessing hydroxyl, bromo, and nitro groups in the structure. Among the compounds prepared, 18 and 19 have shown much stronger inhibition of tyrosinase monophenolase function than arbutin used as a positive control. Both compounds 18 and 19 possess para-hydroxyphenyl moiety in their structure, which might reinforce the importance of p-hydroxyphenyl group in the tyrosinase inhibitory process. In the DPPH radical scavenging activity test, none of the compounds even 18 and 19 showed significant antioxidant activity. The results suggest that elaborate adjustment of diphenyl ether analogues with proper substituents have potential to be developed as new skin whitening agents working on the tyrosinase function.
DOI
10.5012/bkcs.2010.31.5.1319
Appears in Collections:
약학대학 > 약학과 > Journal papers
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