DSpace at EWHA: Synthesis and biological evaluation of 2-pyridyl-substituted pyrazoles and imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors

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DC Field	Value	Language
dc.contributor.author	김대기	*
dc.date.accessioned	2016-08-28T12:08:24Z	-
dc.date.available	2016-08-28T12:08:24Z	-
dc.date.issued	2010	*
dc.identifier.issn	0960-894X	*
dc.identifier.other	OAK-6679	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/220873	-
dc.description.abstract	A series of 2-pyridyl-substituted pyrazoles (16a-d, 17, 18, and 28a-e) and imidazoles (22 and 23) has been synthesized and evaluated for their ALK5 inhibitory activity in cell-based luciferase reporter assays. Among them, 3-(3-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)-1H-pyrazole-1-carbothioamido)benzamide (28c) showed 96% and 93% inhibition at 0.1 μM in luciferase reporter assays using HaCaT cells transiently transfected with p3TP-luc reporter construct and ARE-luc reporter construct, respectively. © 2010 Elsevier Ltd. All rights reserved.	*
dc.language	English	*
dc.title	Synthesis and biological evaluation of 2-pyridyl-substituted pyrazoles and imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors	*
dc.type	Article	*
dc.relation.issue	14	*
dc.relation.volume	20	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	4228	*
dc.relation.lastpage	4232	*
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry Letters	*
dc.identifier.doi	10.1016/j.bmcl.2010.05.032	*
dc.identifier.wosid	WOS:000279258800053	*
dc.identifier.scopusid	2-s2.0-77953873137	*
dc.author.google	Dewang P.M.	*
dc.author.google	Kim D.-K.	*
dc.contributor.scopusid	김대기(35083694200)	*
dc.date.modifydate	20240118164500	*