View : 14 Download: 0

Effects of protostane-type triterpenoids on the 5-HT3A receptor-mediated ion current in Xenopus oocytes

Title
Effects of protostane-type triterpenoids on the 5-HT3A receptor-mediated ion current in Xenopus oocytes
Authors
Lee J.-H.Lee Y.-J.Kang S.-W.Kim Y.Shin M.Hong M.Seo E.-K.Kim S.-H.Nah S.-Y.Bae H.
Ewha Authors
서은경
SCOPUS Author ID
서은경scopus
Issue Date
2010
Journal Title
Brain Research
ISSN
0006-8993JCR Link
Citation
vol. 1331, pp. 20 - 27
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Alisol derivatives are unique protostane-type triterpenoid compounds that are isolated from Alismatis rhizoma, which is a well-known traditional medicine in East Asia. In the present study, we investigated the effects of protostane-type triterpenoids (AA, Alisol A; AB, Alisol B; AB-ac, Alisol B 23-acetate; AC-ac, Alisol C 23-aceteate) on 5-HT-induced currents mediated by the human 5-HT3A receptor expressed in Xenopus laevis oocytes. Co-treatment with triterpenoids regulated the 5-HT-induced inward peak current in a concentration-dependent and reversible manner. In addition, regulation of I5-HT by triterpenoids occurred in a non-competitive manner. Taken together, these results indicate that triterpenoids may regulate the 5-HT3A receptors that are expressed in Xenopus oocytes. Furthermore, this regulation of the ligand-gated ion channel activity by triterpenoids may be one of the pharmacological actions of Alismatis rhizoma. © 2010 Elsevier B.V. All rights reserved.
DOI
10.1016/j.brainres.2010.03.041
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE