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Zn2+ enhances the intrinsic bursting activity of a rat thalamic relay neuron

Title
Zn2+ enhances the intrinsic bursting activity of a rat thalamic relay neuron
Authors
Noh J.Choi H.-J.Chung J.-M.
Ewha Authors
정준모
SCOPUS Author ID
정준모scopus
Issue Date
2010
Journal Title
Neuroscience Research
ISSN
0168-0102JCR Link
Citation
vol. 67, no. 1, pp. 95 - 97
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Although zinc ion (Zn2+) reduced the low-threshold T-type Ca2+ current of a rat thalamic relay neuron (TRN), we observed that Zn2+ increased a bursting activity of TRN by altering the generation and maintenance of low-threshold spike (LTS). Interestingly and importantly, Zn2+ shifted dramatically the voltage-dependence of both steady-state inactivation and activation of the transient A-type K+ current (IA) to a depolarizing direction. As IA is one of the main factors in shaping thalamic LTS, such alterations of gating properties of IA would contribute to the enhancement of TRN excitability under Zn2+. © 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society.
DOI
10.1016/j.neures.2010.01.008
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자연과학대학 > 생명과학전공 > Journal papers
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