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Roles of human INO80 chromatin remodeling enzyme in DNA replication and chromosome segregation suppress genome instability

Title
Roles of human INO80 chromatin remodeling enzyme in DNA replication and chromosome segregation suppress genome instability
Authors
Hur S.-K.Park E.-J.Han J.E.Kim Y.-A.Kim J.-D.Kang D.Kwon J.
Ewha Authors
권종범강동민허신경
SCOPUS Author ID
권종범scopus; 강동민scopus; 허신경scopus
Issue Date
2010
Journal Title
Cellular and Molecular Life Sciences
ISSN
1420-682XJCR Link
Citation
vol. 67, no. 13, pp. 2283 - 2296
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Although INO80 chromatin remodeling enzyme has been shown in yeast to play roles in non-transcriptional nuclear processes such as DNA replication, its cellular functions in higher eukaryotes have remained largely unexplored. Here, we provide evidence that human INO80 (hINO80) participates in both DNA replication and chromosome segregation during the normal cell division cycle. hINO80 binds to chromatin localizing at replication forks during the S-phase, and is required for efficient DNA synthesis and S-phase progression. Unexpectedly, hINO80 associates with spindle microtubule during mitosis, and its deficiency leads to defective microtubule assembly and abnormal chromosome segregation. Consistent with these results, hINO80 is critical for suppressing aneuploidy and structural chromosome abnormalities. This work therefore not only emphasizes the evolutionary importance of INO80 in DNA replication but also reveals a new role for this remodeler in chromosome segregation, both of which likely come into play in maintaining the genome integrity. © Springer Basel AG 2010.
DOI
10.1007/s00018-010-0337-3
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자연과학대학 > 생명과학전공 > Journal papers
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