Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2016-08-28T12:08:08Z | - |
dc.date.available | 2016-08-28T12:08:08Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0968-0896 | * |
dc.identifier.other | OAK-6497 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220723 | - |
dc.description.abstract | A new series of 2,4-diphenyl-6-aryl pyridines containing hydroxyl group(s) at the ortho, meta, or para position of the phenyl ring were synthesized, and evaluated for topoisomerase I and II inhibitory activity and cytotoxicity against several human cancer cell lines for the development of novel anticancer agents. Structure-activity relationship study revealed that the substitution of hydroxyl group(s) increased topoisomerase I and II inhibitory activity in the order of meta > para > ortho position. Substitution of hydroxyl group on the para position showed better cytotoxicity. © 2010 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 3066 | * |
dc.relation.lastpage | 3077 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.bmc.2010.03.051 | * |
dc.identifier.wosid | WOS:000277083400010 | * |
dc.identifier.scopusid | 2-s2.0-77951204579 | * |
dc.author.google | Karki R. | * |
dc.author.google | Thapa P. | * |
dc.author.google | Kang M.J. | * |
dc.author.google | Jeong T.C. | * |
dc.author.google | Nam J.M. | * |
dc.author.google | Kim H.-L. | * |
dc.author.google | Na Y. | * |
dc.author.google | Cho W.-J. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Lee E.-S. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |