Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정병문 | * |
dc.date.accessioned | 2016-08-28T12:08:03Z | - |
dc.date.available | 2016-08-28T12:08:03Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0959-9428 | * |
dc.identifier.other | OAK-6442 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220679 | - |
dc.description.abstract | Poly(ethylene glycol)-conjugated polypeptides have been drawing attention as a biomaterial as well as a pharmaceutical agent. In this paper, we synthesized a series of poly(ethylene glycol)-poly(l-alanine) block copolymers (PEG-l-PA) and investigated the block length effect on (1) the secondary structure of the PA, (2) the nanostructure of the self-assembled amphiphilic PEG-l-PA, and (3) the thermosensitivity of the PEG-l-PA aqueous solution. First, the molecular weight of the l-PA was fixed at 700-760 Daltons and that of the conjugated PEG varied over 1,000, 2,000, and 5,000 Daltons. l-PA with an antiparallel β-sheet structure in water transformed into an α-helical structure, and the self-assembled nanostructure of PEG-l-PA changed from a fibrous structure to a spherical micellar structure as the molecular weight of conjugated PEG increased. Then, when the molecular weight changed from 700 to 1,500 Daltons at a fixed molecular weight of PEG at 2,000, similar transitions involving antiparallel β-sheets changing to α-helices, and fibers to spherical micelles were observed. The polymer aqueous solution underwent a sol-to-gel transition as the temperature increased in a high polymer concentration range of 3-14 wt%. Interestingly, the transition temperature did not follow the simple rule that a more hydrophobic polymer has a lower transition temperature. This paper suggests that the control of PEG molecular weight in PEG-conjugated polypeptide biomaterials is important in that it affects the secondary structure of the polypeptide, the nanoassembled morphology, and the thermosensitivity of the polymer. © The Royal Society of Chemistry 2010. | * |
dc.language | English | * |
dc.title | Block length affects secondary structure, nanoassembly and thermosensitivity of poly(ethylene glycol)-poly(l-alanine) block copolymers | * |
dc.type | Article | * |
dc.relation.issue | 17 | * |
dc.relation.volume | 20 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 3416 | * |
dc.relation.lastpage | 3421 | * |
dc.relation.journaltitle | Journal of Materials Chemistry | * |
dc.identifier.doi | 10.1039/b922956f | * |
dc.identifier.wosid | WOS:000276553300010 | * |
dc.identifier.scopusid | 2-s2.0-77953039799 | * |
dc.author.google | Choi Y.Y. | * |
dc.author.google | Jang J.H. | * |
dc.author.google | Park M.H. | * |
dc.author.google | Choi B.G. | * |
dc.author.google | Chi B. | * |
dc.author.google | Jeong B. | * |
dc.contributor.scopusid | 정병문(7102237959) | * |
dc.date.modifydate | 20240118155902 | * |