Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정준모 | * |
dc.date.accessioned | 2016-08-28T12:08:00Z | - |
dc.date.available | 2016-08-28T12:08:00Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0168-0102 | * |
dc.identifier.other | OAK-6416 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220655 | - |
dc.description.abstract | To elucidate biophysical mechanisms underlying the Zn2+ block on the low-threshold T-type Ca2+ current (IT), we examined the Zn2+-induced alterations of gating properties of IT of a rat thalamic relay neuron and of α1G channels expressed in HEK-293 cells, using a whole-cell voltage clamp technique. The effect of Zn2+ block depended upon holding potentials but not test potentials, indicating that, the greater the inactivation, the less Zn2+ blocked IT. Except for the inactivation near the activation threshold of IT, no significant changes in the kinetics of activation and inactivation were induced by Zn2+. In contrast, the rates of both de-inactivation and deactivation were dramatically increased by Zn2+, and moreover the channels were rapidly re-blocked upon re-polarization under Zn2+. Furthermore, the outward current via α1G channel was almost insensitive to Zn2+. All these results imply that Zn2+ alters the gating properties of IT mainly by accelerating its deactivation process. © 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. | * |
dc.language | English | * |
dc.title | A novel mechanism of zinc block on α1G-like low-threshold T-type Ca2+ channels in a rat thalamic relay neuron | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 66 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 353 | * |
dc.relation.lastpage | 358 | * |
dc.relation.journaltitle | Neuroscience Research | * |
dc.identifier.doi | 10.1016/j.neures.2009.12.005 | * |
dc.identifier.wosid | WOS:000276148300004 | * |
dc.identifier.scopusid | 2-s2.0-77049105127 | * |
dc.author.google | Noh J. | * |
dc.author.google | Kim M.-k. | * |
dc.author.google | Chung J.-m. | * |
dc.contributor.scopusid | 정준모(9233608000) | * |
dc.date.modifydate | 20240415121825 | * |