Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이공주 | * |
dc.contributor.author | 이수영 | * |
dc.contributor.author | 강상원 | * |
dc.contributor.author | 김재상 | * |
dc.contributor.author | 이두재 | * |
dc.date.accessioned | 2016-08-28T12:08:58Z | - |
dc.date.available | 2016-08-28T12:08:58Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 1932-6203 | * |
dc.identifier.other | OAK-6388 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220631 | - |
dc.description.abstract | Cytoplasmic presence of Hsp60, which is principally a nuclear gene-encoded mitochondrial chaperonin, has frequently been stated, but its role in intracellular signaling is largely unknown. In this study, we demonstrate that the cytosolic Hsp60 promotes the TNF-α-mediated activation of the IKK/NF-kB survival pathway via direct interaction with IKKa/b in the cytoplasm. Selective loss or blockade of cytosolic Hsp60 by specific antisense oligonucleotide or neutralizing antibody diminished the IKK/NF-kB activation and the expression of NF-kB target genes, such as Bfl-1/A1 and MnSOD, which thus augmented intracellular ROS production and ASK1-dependent cell death, in response to TNF-α. Conversely, the ectopic expression of cytosol-targeted Hsp60 enhanced IKK/NF-kB activation. Mechanistically, the cytosolic Hsp60 enhanced IKK activation via upregulating the activation-dependent serine phosphorylation in a chaperone-independent manner. Furthermore, transgenic mouse study showed that the cytosolic Hsp60 suppressed hepatic cell death induced by diethylnitrosamine in vivo. The cytosolic Hsp60 is likely to be a regulatory component of IKK complex and it implicates the first mitochondrial factor that regulates cell survival via NF-kB pathway. © 2010 Chun et al. | * |
dc.language | English | * |
dc.title | Cytosolic Hsp60 Is Involved in the NF-kB-Dependent Survival of Cancer Cells via IKK Regulation | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 5 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | PLoS ONE | * |
dc.identifier.doi | 10.1371/journal.pone.0009422 | * |
dc.identifier.wosid | WOS:000275894400003 | * |
dc.identifier.scopusid | 2-s2.0-79952116841 | * |
dc.author.google | Chun J.N. | * |
dc.author.google | Choi B. | * |
dc.author.google | Lee K.W. | * |
dc.author.google | Lee D.J. | * |
dc.author.google | Kang D.H. | * |
dc.author.google | Lee J.Y. | * |
dc.author.google | Song I.S. | * |
dc.author.google | Kim H.I. | * |
dc.author.google | Lee S.-H. | * |
dc.author.google | Kim H.S. | * |
dc.author.google | Lee N.K. | * |
dc.author.google | Lee S.Y. | * |
dc.author.google | Lee K.-J. | * |
dc.author.google | Kim J. | * |
dc.author.google | Kang S.W. | * |
dc.contributor.scopusid | 이공주(7501497635;57191532162) | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.contributor.scopusid | 강상원(55731433900) | * |
dc.contributor.scopusid | 김재상(8643335800) | * |
dc.contributor.scopusid | 이두재(26652094200) | * |
dc.date.modifydate | 20240426141057 | * |