View : 20 Download: 0

Tripodal amphiphiles tunable for self-assembly to polymersomes

Title
Tripodal amphiphiles tunable for self-assembly to polymersomes
Authors
Jun Y.J.Park M.K.Jadhav V.B.Song J.H.Chae S.W.Lee H.J.Park K.S.Jeong B.Choy J.H.Sohn Y.S.
Ewha Authors
손연수이화정정병문최진호
SCOPUS Author ID
손연수scopus; 이화정scopus; 정병문scopus; 최진호scopus
Issue Date
2010
Journal Title
Journal of Controlled Release
ISSN
0168-3659JCR Link
Citation
vol. 142, no. 1, pp. 132 - 137
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Cyclotriphosphazenes grafted with equimolar amounts of a hydrophilic polyethylene glycol and a hydrophobic oligopeptide in cis-nongeminal way form a new class of tripodal amphiphiles allowing both intra- and intermolecular hydrophobic interactions that differ from linear block copolymer amphiphiles. It has been found in this study that the tripodal amphiphiles can be tuned for self-assembly from micelles to bilayered polymersomes by controlling the hydrophobicity of the oligopeptide grafted. For instance, the tripodal amphiphiles with an intermediate hydrophobicity (0<log P<1) (P=[solute] n-octanol/[solute] water) reassemble from initially formed micelles into polymersomes, whereas the trimers bearing highly hydrophobic oligopeptides (log P>1) remain as stable micelles in aqueous solution. These biodegradable polymersomes exhibit outstanding physicochemical properties required for practical drug delivery and other biomedical applications. In particular, the cyclic phosphazene trimer platinated with a hydrophobic cis-bis(cyclohexylamine)Pt-moiety forms very stable polymersomes with excellent tumor selectivity by EPR effect and seems to be a promising candidate for preclinical studies. © 2009 Elsevier B.V.
DOI
10.1016/j.jconrel.2009.10.004
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE