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Fluorescein-functionalized silica nanoparticles as a selective fluorogenic chemosensor for Cu2+ in living cells

Title
Fluorescein-functionalized silica nanoparticles as a selective fluorogenic chemosensor for Cu2+ in living cells
Authors
Seo S.Lee H.Y.Park M.Lim J.M.Kang D.Yoon J.Jung J.H.
Ewha Authors
윤주영강동민
SCOPUS Author ID
윤주영scopus; 강동민scopus
Issue Date
2010
Journal Title
European Journal of Inorganic Chemistry
ISSN
1434-1948JCR Link
Citation
no. 6, pp. 843 - 847
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Fluorescein-functionalized silica nanoparticles (1) were prepared by sol-gel reaction, and their optical sensing abilities were studied towards finding a new type of synthetic fluorogenic chemosensor for imaging Cu 2+ ions in living cells. Interestingly, upon addition of Cu 2+ in a H2O suspension of 1 at pH 7.4, 1 displays large chelation-enhanced quenching (CHBQ) effects with Cu2+. With the exception of Cu2+, no significant fluorescence intensity changes were observed in the experiments with the other metal ions. These findings confirm that 1 can be useful as a fluorogenic-sensing material for the selective detection of Cu2+ in the presence of other metal ions. This is a rare example of chromogenic sensing of a specific metal ion by functional inorganic nanomaterials. The emission change observed for chemosensor 1 in the presence of Cu2+ is reversible by the addition of EDTA. Furthermore, the fluorescein-functionalized silica nanoparticles act as a new type of synthetic fluorogenic chemosensor for imaging Cu2+ ions in living cells. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA,.
DOI
10.1002/ejic.200901039
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자연과학대학 > 화학·나노과학전공 > Journal papers
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