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Genetic engineering of macrolide biosynthesis: Past advances, current state, and future prospects

Title
Genetic engineering of macrolide biosynthesis: Past advances, current state, and future prospects
Authors
Park S.R.Han A.R.Ban Y.-H.Yoo Y.J.Kim E.J.Yoon Y.J.
Ewha Authors
윤여준
SCOPUS Author ID
윤여준scopus
Issue Date
2010
Journal Title
Applied Microbiology and Biotechnology
ISSN
0175-7598JCR Link
Citation
vol. 85, no. 5, pp. 1227 - 1239
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Polyketides comprise one of the major families of natural products. They are found in a wide variety of bacteria, fungi, and plants and include a large number of medically important compounds. Polyketides are biosynthesized by polyketide synthases (PKSs). One of the major groups of polyketides are the macrolides, the activities of which are derived from the presence of a macrolactone ring to which one or more 6-deoxysugars are attached. The core macrocyclic ring is biosynthesized from acyl-CoA precursors by PKS. Genetic manipulation of PKS-encoding genes can result in predictable changes in the structure of the macrolactone component, many of which are not easily achieved through standard chemical derivatization or total synthesis. Furthermore, many of the changes, including post-PKS modifications such as glycosylation and oxidation, can be combined for further structural diversification. This review highlights the current state of novel macrolide production with a focus on the genetic engineering of PKS and post-PKS tailoring genes. Such engineering of the metabolic pathways for macrolide biosynthesis provides attractive alternatives for the production of diverse non-natural compounds. Other issues of importance, including the engineering of precursor pathways and heterologous expression of macrolide biosynthetic genes, are also considered. © 2009 Springer-Verlag.
DOI
10.1007/s00253-009-2326-8
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자연과학대학 > 화학·나노과학전공 > Journal papers
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