Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 오억수 | - |
dc.contributor.author | 김현정 | - |
dc.date.accessioned | 2016-08-28T12:08:43Z | - |
dc.date.available | 2016-08-28T12:08:43Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | OAK-6209 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220475 | - |
dc.description.abstract | Expression of the cell surface adhesion receptor syndecan-2 is known to be involved in the regulation of cancer cell migration. However, the molecular mechanism of syndecan-2-mediated cell migration remains unknown. Here we report that Rac contributes to the regulation of syndecan-2-mediated cancer cell migration. Overexpression of syndecan-2 enhanced migration and invasion of human colon adenocarcinoma cells Caco-2 and HCT116 cells. In parallel with the increased cell migration/invasion, syndecan-2 overexpression enhanced Rac activity, while dominant negative Rac (RacN17) diminished syndecan-2-mediated increased cancer cell migration. In addition syndecan-2 expression increased membrane localization of Tiam1 and syndecan-2-mediated cell migration/invasion of Caco-2 cells was diminished when Tiam1 levels were knocked-down with small inhibitory RNAs. Furthermore, oligomerization-defective syndecan-2 mutants failed to increase membrane localization of Tiam1, activation of Rac and subsequent cell migration of both Caco-2 and HCT116 cells. Taken together, these results suggest that syndecan-2 regulates cell migration of colon carcinoma cells through Tiam1-dependent Rac activation in colon cancer cells. © 2009 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.title | Syndecan-2 regulates cell migration in colon cancer cells through Tiam1-mediated Rac activation | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 391 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 921 | - |
dc.relation.lastpage | 925 | - |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.11.165 | - |
dc.identifier.wosid | WOS:000273624500162 | - |
dc.identifier.scopusid | 2-s2.0-72949114645 | - |
dc.author.google | Choi Y. | - |
dc.author.google | Kim H. | - |
dc.author.google | Chung H. | - |
dc.author.google | Hwang J.-S. | - |
dc.author.google | Shin J.-A. | - |
dc.author.google | Han I.-O. | - |
dc.author.google | Oh E.-S. | - |
dc.contributor.scopusid | 오억수(7101967153) | - |
dc.date.modifydate | 20211001081000 | - |