Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강상원 | * |
dc.date.accessioned | 2016-08-28T12:08:42Z | - |
dc.date.available | 2016-08-28T12:08:42Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0008-6363 | * |
dc.identifier.other | OAK-6204 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220470 | - |
dc.description.abstract | AimsA reduction in the level of thioredoxin 1 (Trx1) has been proposed as a possible mechanism for the tumor-specific growth arrest caused by inhibition of histone deacetylases (HDACs). In this study, we investigated the effect of trichostatin A (TSA), a potent HDAC inhibitor, on the proliferation and migration of vascular smooth muscle cells (VSMCs), and we examined the role of reduced Trx1 levels in this effect.Methods and resultsTSA treatment time-dependently decreased Trx1 expression in rat VSMCs at both the mRNA and protein levels. It also enhanced platelet-derived growth factor (PDGF)-induced proliferation and migration of the VSMCs. By potentiating Akt phosphorylation, the siRNA-induced downregulation of Trx1 also enhanced VSMC proliferation and migration in response to PDGF or serum treatment. Consistent with these results, TSA administration increased neointimal thickening in a murine model of post-angioplastic restenosis.ConclusionThese data demonstrate that TSA enhances vascular proliferative activity by downregulating Trx1, thus activating an Akt-dependent pathway. Our results indicate that, in addition to its apoptotic effects in tumour cells, the downregulation of Trx1 has a proliferative role in primary VSMCs. | * |
dc.language | English | * |
dc.title | Trichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1 | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 85 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 241 | * |
dc.relation.lastpage | 249 | * |
dc.relation.journaltitle | Cardiovascular Research | * |
dc.identifier.doi | 10.1093/cvr/cvp263 | * |
dc.identifier.wosid | WOS:000273557200029 | * |
dc.identifier.scopusid | 2-s2.0-72049083765 | * |
dc.author.google | Song S. | * |
dc.author.google | Kang S.W. | * |
dc.author.google | Choi C. | * |
dc.contributor.scopusid | 강상원(55731433900) | * |
dc.date.modifydate | 20240118155300 | * |