Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김상태 | - |
dc.contributor.author | 손형진 | - |
dc.date.accessioned | 2016-08-28T12:08:39Z | - |
dc.date.available | 2016-08-28T12:08:39Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.other | OAK-6157 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220430 | - |
dc.description.abstract | Our previous microarray analysis identified a neuroprotective protein Oxi-α, that was down-regulated during oxidative stress (OS)-induced cell death in dopamine neurons [Neurochem. Res. (2004) vol. 29, pp. 1223]. Here we find that the phylogenetically conserved Oxi-α protects against OS by a novel mechanism: Activation of the mammalian target of rapamycin (mTOR) kinase and subsequent repression of autophagic vacuole accumulation and cell death. To the best of our knowledge, Oxi-α is the first molecule discovered in dopamine neurons, which activates mTOR kinase. Indeed, the down-regulation of Oxi-α by OS suppresses the activation of mTOR kinase. The pathogenic effect of down-regulated Oxi-α was confirmed by gene-specific knockdown experiment, which resulted in not only the repression of mTOR kinase and the subsequent phosphorylation of p70 S6 kinase and 4E-BP1, but also enhanced susceptibility to OS. In accordance with these observations, treatment with rapamycin, an mTOR inhibitor and autophagy inducer, potentiated OS-induced cell death, while similar treatment with an autophagy inhibitor, 3-methyladenine protected the dopamine cells. Our findings present evidence for the presence of a novel class of molecule involved in autophagic cell death triggered by OS in dopamine neurons. © 2009 International Society for Neurochemistry. | - |
dc.language | English | - |
dc.title | A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 112 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 366 | - |
dc.relation.lastpage | 376 | - |
dc.relation.journaltitle | Journal of Neurochemistry | - |
dc.identifier.doi | 10.1111/j.1471-4159.2009.06463.x | - |
dc.identifier.wosid | WOS:000272996600005 | - |
dc.identifier.scopusid | 2-s2.0-72849127046 | - |
dc.author.google | Choi K.-C. | - |
dc.author.google | Kim S.-H. | - |
dc.author.google | Ha J.-Y. | - |
dc.author.google | Kim S.-T. | - |
dc.author.google | Son J.H. | - |
dc.contributor.scopusid | 손형진(7203086503) | - |
dc.date.modifydate | 20220119162545 | - |