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dc.contributor.author오억수-
dc.date.accessioned2016-08-28T12:08:36Z-
dc.date.available2016-08-28T12:08:36Z-
dc.date.issued2009-
dc.identifier.issn0021-9258-
dc.identifier.otherOAK-6123-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/220404-
dc.description.abstractAlthough elevated syndecan-2 expression is known to be crucial for the tumorigenic activity in colon carcinoma cells, how syndecan-2 regulates colon cancer is unclear. In human colon adenocarcinoma tissue samples, we found that both mRNA and protein expression of syndecan-2 were increased, compared with the neighboring normal epithelium, suggesting that syndecan-2 plays functional roles in human colon cancer cells. Consistent with this notion, syndecan-2-overexpressing HT-29 colon adenocarcinoma cells showed enhanced migration/invasion, anchorage-independent growth, and primary tumor formation in nude mice, paralleling their morphological changes into highly tumorigenic cells. In addition, our experiments revealed that syndecan-2 enhanced both expression and secretion of matrix metalloproteinase-7 (MMP-7), directly interacted with pro-MMP-7, and potentiated the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7. Collectively, these data strongly suggest that syndecan-2 functions as a docking receptor for pro-MMP-7 in colon cancer cells. © 2009 by The American Society for Biochemistry and Molecular Biology, Inc.-
dc.languageEnglish-
dc.titleSyndecan-2 functions as a docking receptor for pro-matrix metalloproteinase-7 in human colon cancer cells-
dc.typeArticle-
dc.relation.issue51-
dc.relation.volume284-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage35692-
dc.relation.lastpage35701-
dc.relation.journaltitleJournal of Biological Chemistry-
dc.identifier.doi10.1074/jbc.M109.054254-
dc.identifier.wosidWOS:000272645600047-
dc.identifier.scopusid2-s2.0-72149109011-
dc.author.googleRyu H.-Y.-
dc.author.googleLee J.-
dc.author.googleYang S.-
dc.author.googlePark H.-
dc.author.googleChoi S.-
dc.author.googleJung K.-C.-
dc.author.googleLee S.-T.-
dc.author.googleSeong J.-K.-
dc.author.googleHan I.-O.-
dc.author.googleOh E.-S.-
dc.contributor.scopusid오억수(7101967153)-
dc.date.modifydate20190901081003-


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