Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이원준 | - |
dc.date.accessioned | 2016-08-28T12:08:36Z | - |
dc.date.available | 2016-08-28T12:08:36Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | OAK-6115 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220397 | - |
dc.description.abstract | Although insulin-like growth factor-I (IGF-I) and androgen receptor (AR) are well known effectors of skeletal muscle, the molecular mechanism by which signaling pathways integrating AR and IGF-I in skeletal muscle cells has not been previously examined. In this study, the role of PI3K/Akt on IGF-I-induced gene expression and activation of AR in skeletal muscle cells was investigated. C2C12 cells were treated with IGF-I in the absence or presence of inhibitors of PI3K/Akt pathway (LY294002 and Wortmannin). Inhibition of the PI3K/Akt pathway with LY294002 or Wortmannin led to a significant decrease in IGF-I-induced AR phosphorylation and total AR protein expression. Furthermore, IGF-I-induced AR mRNA and skeletal α-actin mRNA were blocked by LY294002 or Wortmannin. Confocal images showed that IGF-I-induced AR translocation from cytosol to nucleus was inhibited significantly in response to treatment with LY294002 or Wortmannin. The present results suggest that modulating effect of IGF-I on AR gene expression and activation in C2C12 mouse skeletal muscle cells is mediated at least in part by the PI3K/Akt pathway. © 2009 KSMCB. | - |
dc.language | English | - |
dc.title | Insulin-like growth factor-I-induced androgen receptor activation is mediated by the PI3K/Akt pathway in C2C12 skeletal muscle cells | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 28 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 495 | - |
dc.relation.lastpage | 499 | - |
dc.relation.journaltitle | Molecules and Cells | - |
dc.identifier.doi | 10.1007/s10059-009-0142-8 | - |
dc.identifier.wosid | WOS:000272539000012 | - |
dc.identifier.scopusid | 2-s2.0-72949113217 | - |
dc.author.google | Lee W.J. | - |
dc.contributor.scopusid | 이원준(55934371200) | - |
dc.date.modifydate | 20211210153240 | - |