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Over-expression of translationally controlled tumor protein in lens epithelial cells seems to be associated with cataract development

Title
Over-expression of translationally controlled tumor protein in lens epithelial cells seems to be associated with cataract development
Authors
Kim M.-J.Lyu J.Sohn K.-B.Kim M.Cho M.-C.Joo C.-K.Lee K.
Ewha Authors
이경림
SCOPUS Author ID
이경림scopus
Issue Date
2009
Journal Title
Transgenic Research
ISSN
0962-8819JCR Link
Citation
vol. 18, no. 6, pp. 953 - 960
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Inhibition of Na,K-ATPase causes opacification of the lens through abnormal increases in sodium and calcium levels, disturbed osmotic equilibrium, activation of proteolytic enzymes and cell damage. We previously identified Translationally Controlled Tumor Protein (TCTP) as a cytoplasmic repressor of Na,K-ATPase and confirmed that systemic hypertension is induced in transgenic mice over-expressing TCTP through inhibition of vascular Na,K-ATPase and increased intracellular calcium mobilization. In the current study, we confirmed the role of TCTP in causing intracellular calcium mobilization by inhibiting Na,K-ATPase in a human lens epithelial cell line and further showed that some of the TCTP-transgenic mice develop cataracts with an incidence rate of 7.38% compared to 1.47% in controls. We demonstrated that TCTP acts as a cataractogenic factor through the repression of Na, K-ATPase activity and calcium mobilization in lens epithelial cells. © Springer Science+Business Media B.V. 2009.
DOI
10.1007/s11248-009-9283-y
Appears in Collections:
약학대학 > 약학과 > Journal papers
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