Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2016-08-28T12:08:29Z | - |
dc.date.available | 2016-08-28T12:08:29Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0960-894X | * |
dc.identifier.other | OAK-6024 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220325 | - |
dc.description.abstract | A total of seven new oxyranylmethyloxy or thiiranylmethyloxy group substituted 5-azaxanthones and -acridones analogues were synthesized and tested for their biological activities for cancer cell lines and topoisomerases. Among the compounds, compound 5, 3-thiiranylmethyloxy-1-hydroxy-5-azaxanthone, showed effective topoisomerase I inhibitory activity, 50% and 27% inhibition ratio at 100 and 20 μM, respectively. This result is the first finding of the function of 5-azaxanthone compounds for topoisomerase I inhibition and can provide a novel skeleton for the anticancer drug development process. © 2009 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors | * |
dc.type | Article | * |
dc.relation.issue | 23 | * |
dc.relation.volume | 19 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 6766 | * |
dc.relation.lastpage | 6769 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry Letters | * |
dc.identifier.doi | 10.1016/j.bmcl.2009.09.091 | * |
dc.identifier.wosid | WOS:000271430400060 | * |
dc.identifier.scopusid | 2-s2.0-71749084307 | * |
dc.author.google | Cho H.-J. | * |
dc.author.google | Jung M.-J. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Na Y. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |