Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 윤영대 | - |
dc.contributor.author | 박인영 | - |
dc.date.accessioned | 2016-08-28T12:08:22Z | - |
dc.date.available | 2016-08-28T12:08:22Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | OAK-5909 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220252 | - |
dc.description.abstract | TSAd/Lad is a T cell adaptor molecule involved in p56 lck -mediated T cell activation. To investigate the functions of TSAd in T cells, we generated transgenic (TG) mice expressing the SH2 domain of TSAd (TSAd-SH2) under the control of the p56 lck proximal promoter. In T cells from TSAd-SH2 TG mice, T cell receptor (TCR)-mediated early signaling events, such as Ca 2+ flux and ERK activation, were normal; however, late activation events, such as IL-2 production and proliferation, were significantly reduced. Moreover, TCR-induced cell adhesion to extracellular matrix (ECM) proteins and migration through ECM proteins were defective in T cells from TSAd-SH2 TG mice. Furthermore, the contact hypersensitivity (CHS) reaction, an inflammatory response mainly mediated by T helper 1 (Th1) cells, was inhibited in TSAd-SH2 TG mice. Taken together, these results show that TSAd, particularly the SH2 domain of TSAd, is essential for the effector functions of T cells. © The Korean Society for Molecular and Cellular Biology and Springer Netherlands 2009. | - |
dc.language | English | - |
dc.title | The effector functions of mature T lymphocytes are impaired in transgenic mice expressing the SH2 domain of TSAd/Lad | - |
dc.type | Article | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 28 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 183 | - |
dc.relation.lastpage | 188 | - |
dc.relation.journaltitle | Molecules and Cells | - |
dc.identifier.doi | 10.1007/s10059-009-0121-0 | - |
dc.identifier.wosid | WOS:000270184800006 | - |
dc.identifier.scopusid | 2-s2.0-70349606495 | - |
dc.author.google | Choi Y. | - |
dc.author.google | Park E. | - |
dc.author.google | Ahn E. | - |
dc.author.google | Park I. | - |
dc.author.google | Yun Y. | - |
dc.contributor.scopusid | 윤영대(7201731033) | - |
dc.contributor.scopusid | 박인영(7403243197;56302476200) | - |
dc.date.modifydate | 20230118102324 | - |