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Reverse thermal gelation of PAF-PLX-PAF block copolymer aqueous solution

Title
Reverse thermal gelation of PAF-PLX-PAF block copolymer aqueous solution
Authors
Kim E.H.Joo M.K.Bahk K.H.Park M.H.Chi B.Lee Y.M.Jeong B.
Ewha Authors
정병문이영미
SCOPUS Author ID
정병문scopus; 이영미scopus
Issue Date
2009
Journal Title
Biomacromolecules
ISSN
1525-7797JCR Link
Citation
vol. 10, no. 9, pp. 2476 - 2481
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The aqueous solution of poly(L-Ala-co-L-Phe)-poly(propylene glycol)-poly(ethylene glycol)-poly(propylene glycol)-poly(L-Ala-co-L-Phe) block copolymers (PAF-PLX-PAF) in a concentration range of 6.0-10.0 wt % underwent sol-to-gel transition as the temperature increased from 10 to 50 ° C. Circular dichroism spectra, hydrophobic dye solubilization, dynamic light scattering, and transmission electron microscopy image of the polymer suggest that the polymers form micelles in water, where the hydrophilic (PLX) blocks form a shell and the hydrophobic (PAF) blocks form a core of the micelle. Circular dichroism, FTIR, and 13C NMR spectra suggest that sol-to-gel transition accompanies partial strengthening of the β-sheet structure of PAF and a decrease in molecular motion of the PLX. The sol-to-gel transition temperature could be controlled by varying the molecular weight of PAF and PLX blocks, the ratio of Ala to Phe, and the corresponding secondary structure of the polypeptide. © 2009 American Chemical Society.
DOI
10.1021/bm9004436
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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