Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.contributor.author | 이화정 | * |
dc.contributor.author | 한아름 | * |
dc.date.accessioned | 2016-08-28T12:08:13Z | - |
dc.date.available | 2016-08-28T12:08:13Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 0951-418X | * |
dc.identifier.other | OAK-5542 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220165 | - |
dc.description.abstract | Five phenylbutenoid derivatives from the rhizomes of Zingiber cassumunar Roxb. (Zingiberaceae) were evaluated for their P-glycoprotein (P-gp) inhibitory effects in a P-gp over-expressing multidrug resistant (MDR) human breast cancer cell line, MCF-7/ADR. As a result, a phenylbutenoid dimer, (+)-»ans-3-(3, 4-dimethoxyphenyl)- 4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene (1), exhibited highly potent P-gp inhibitory activity, decreasing the IC50 value of daunomycin (DNM) to 4.31 + 0.40 hm in the cells (DNM IC50 = 37.1 + 0.59 hm). The positive control, verapamil decreased the IC50 value of DNM to 6.94 + 0.40 |Im. Three phenylbutenoid monomers, 24 from this plant, also resulted in a significant decrease in the IC50 values of DNM compared with the control. In particular, compound 1 markedly enhanced [ 3H]-DNM accumulation and significantly reduced [3H]-DNM efflux compared with the control, and this effect was more potent than that of verapamil, a well-known P-gp inhibitor. These results suggest that compound 1 of Z. cassumunar can be developed as a potent chemo-sensitizing agent that reverses P-gp-mediated MDR in human cancer chemotherapy. Copyright © 2008 John Wiley & Sons, Ltd. | * |
dc.language | English | * |
dc.title | Potent modulation of p-glycoprotein activity by naturally occurring phenylbutenoids from zingiber cassumunar | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 23 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 472 | * |
dc.relation.lastpage | 476 | * |
dc.relation.journaltitle | Phytotherapy Research | * |
dc.identifier.doi | 10.1002/ptr.2650 | * |
dc.identifier.wosid | WOS:000265144800004 | * |
dc.identifier.scopusid | 2-s2.0-64549130483 | * |
dc.author.google | Chung S.Y. | * |
dc.author.google | Han A.-R. | * |
dc.author.google | Sung M.K. | * |
dc.author.google | Jung H.J. | * |
dc.author.google | Nam J.-W. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Lee H.J. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 이화정(57102029300) | * |
dc.contributor.scopusid | 한아름(56278315000;34769874800) | * |
dc.date.modifydate | 20240130112016 | * |