Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이상국 | * |
dc.contributor.author | 서은경 | * |
dc.contributor.author | 한아름 | * |
dc.date.accessioned | 2016-08-28T12:08:12Z | - |
dc.date.available | 2016-08-28T12:08:12Z | - |
dc.date.issued | 2009 | * |
dc.identifier.issn | 1567-5769 | * |
dc.identifier.other | OAK-5496 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220159 | - |
dc.description.abstract | Eleutherine americana Merr. et Heyne (Iridaceae) has been used as a folk medicine for the treatment of coronary disorders and wound-healing. In our previous phytochemical study, several pyranonaphthoquinoids, including (-)-isoeleutherin, were isolated from the bulbs of E. americana. Because inhibitors of inducible nitric oxide synthase (iNOS) might be useful as anti-inflammatory agents, we investigated the potential of pyranonaphthoquinoids to inhibit iNOS activity. We found that (-)-isoeleutherin inhibits lipopolysaccharide (LPS)-stimulated induction of nitric oxide (NO) in a dose-dependent manner (IC50 = 7.4 μM). Using western blots and reverse transcription-polymerase chain reaction, we showed that (-)-isoeleutherin suppresses the expression of iNOS protein and mRNA. In addition, (-)-isoeleutherin inhibited the expression of various cytokines such as interleukin-1β and interferon-β. Activation of the transcriptional activity of NF-κB by LPS was also inhibited by treatment with (-)-isoeleutherin, suggesting that (-)-isoeleutherin-mediated suppression of iNOS expression is associated with the regulation of transcription factor NF-κB. These findings suggest that (-)-isoeleutherin might be a novel anti-inflammatory agent, and that it may work by inhibiting NFkB activation in macrophages. © 2008 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.title | Suppression of inducible nitric oxide synthase by (-)-isoeleutherin from the bulbs of Eleutherine americana through the regulation of NF-κB activity | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 298 | * |
dc.relation.lastpage | 302 | * |
dc.relation.journaltitle | International Immunopharmacology | * |
dc.identifier.doi | 10.1016/j.intimp.2008.12.003 | * |
dc.identifier.wosid | WOS:000264507100006 | * |
dc.identifier.scopusid | 2-s2.0-60249085139 | * |
dc.author.google | Song S.-H. | * |
dc.author.google | Min H.-Y. | * |
dc.author.google | Han A.-R. | * |
dc.author.google | Nam J.-W. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Seoung Woo Park | * |
dc.author.google | Sang Hyung Lee | * |
dc.author.google | Sang Kook Lee | * |
dc.contributor.scopusid | 이상국(36067620500) | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 한아름(56278315000;34769874800) | * |
dc.date.modifydate | 20240130112016 | * |