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An effective and general method for the highly regioselective synthesis of 1-phenylpyrazoles from β-enaminoketoesters, tandem Blaise-acylation adducts

Title
An effective and general method for the highly regioselective synthesis of 1-phenylpyrazoles from β-enaminoketoesters, tandem Blaise-acylation adducts
Authors
Ko Y.O.Chun Y.S.Park C.-L.Kim Y.Shin H.Ahn S.Hong J.Lee S.-G.
Ewha Authors
김영미이상기
SCOPUS Author ID
김영미scopus; 이상기scopus
Issue Date
2009
Journal Title
Organic and Biomolecular Chemistry
ISSN
1477-0520JCR Link
Citation
vol. 7, no. 6, pp. 1132 - 1136
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
An effective and general route for the regioselective synthesis of 1-phenylpyrazoles has been developed from β-enaminoketoesters prepared by tandem Blaise-acylation. This method is applicable to a very broad range of substrates, generating a diverse set of 3-aryl-5-alkyl, 3-alkyl-5-aryl, 3,5-diaryl, and 3,5-dialkyl substituted pyrazoles regioselectively. The dichotomous regioselective synthesis of isotopically discriminated 3-CD 3-5-CH 3 and 3-CH 3-5-CD 3 substituted pyrazoles showcases the power of this protocol. © The Royal Society of Chemistry 2009.
DOI
10.1039/b820324e
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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