DSpace at EWHA: An effective and general method for the highly regioselective synthesis of 1-phenylpyrazoles from β-enaminoketoesters, tandem Blaise-acylation adducts

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An effective and general method for the highly regioselective synthesis of 1-phenylpyrazoles from β-enaminoketoesters, tandem Blaise-acylation adducts

Title: An effective and general method for the highly regioselective synthesis of 1-phenylpyrazoles from β-enaminoketoesters, tandem Blaise-acylation adducts

Authors: Ko Y.O.; Chun Y.S.; Park C.-L.; Kim Y.; Shin H.; Ahn S.; Hong J.; Lee S.-G.

Ewha Authors: 김영미; 이상기

SCOPUS Author ID: 김영미; 이상기

Issue Date: 2009

Journal Title: Organic and Biomolecular Chemistry

ISSN: 1477-0520

Citation: vol. 7, no. 6, pp. 1132 - 1136

Indexed: SCI; SCIE; SCOPUS

Abstract: An effective and general route for the regioselective synthesis of 1-phenylpyrazoles has been developed from β-enaminoketoesters prepared by tandem Blaise-acylation. This method is applicable to a very broad range of substrates, generating a diverse set of 3-aryl-5-alkyl, 3-alkyl-5-aryl, 3,5-diaryl, and 3,5-dialkyl substituted pyrazoles regioselectively. The dichotomous regioselective synthesis of isotopically discriminated 3-CD 3-5-CH 3 and 3-CH 3-5-CD 3 substituted pyrazoles showcases the power of this protocol. © The Royal Society of Chemistry 2009.