Design and synthesis of 5''-iodoneplanocin a and its analogues as potential S-adenosylhomocysteine hydrolase inhibitor

Abstract

5''-Iodoneplanocin A (1) and its analogues 2 and 3 were designed and synthesized as potential SAHH inhibitor via iodocyclopentenol 6, which was prepared using a Michael addition-iodination-elimination process. All final compounds did not show antiviral activity, maybe due to a steric hindrance induced by 5″-iodo substituent.