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Design and synthesis of 5''-iodoneplanocin a and its analogues as potential S-adenosylhomocysteine hydrolase inhibitor

Title
Design and synthesis of 5''-iodoneplanocin a and its analogues as potential S-adenosylhomocysteine hydrolase inhibitor
Authors
Park A.-Y.Kim K.R.Lee H.-R.Kang J.-A.Kim W.H.Chun P.Ahmad P.Jeong L.S.Moon H.R.
Ewha Authors
정낙신
Issue Date
2008
Journal Title
Bulletin of the Korean Chemical Society
ISSN
0253-2964JCR Link
Citation
vol. 29, no. 12, pp. 2487 - 2490
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
5''-Iodoneplanocin A (1) and its analogues 2 and 3 were designed and synthesized as potential SAHH inhibitor via iodocyclopentenol 6, which was prepared using a Michael addition-iodination-elimination process. All final compounds did not show antiviral activity, maybe due to a steric hindrance induced by 5″-iodo substituent.
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약학대학 > 약학과 > Journal papers
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