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Convenient synthesis and evaluation of biological activity of benzyl (2S)-2-[(R)-1-hydroxy-2-oxo-(1-phenethyl)prop-3-ylcarbamoyl]-4-oxopiperidine- (or -4-oxopyrrolidine)-1-carboxylate as novel histone deacetylase inhibitors

Title
Convenient synthesis and evaluation of biological activity of benzyl (2S)-2-[(R)-1-hydroxy-2-oxo-(1-phenethyl)prop-3-ylcarbamoyl]-4-oxopiperidine- (or -4-oxopyrrolidine)-1-carboxylate as novel histone deacetylase inhibitors
Authors
Oh S.Moon H.-I.Jung J.-C.
Ewha Authors
오세관정재철
SCOPUS Author ID
오세관scopus
Issue Date
2008
Journal Title
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
ISSN
0932-0776JCR Link
Citation
vol. 63, no. 11, pp. 1300 - 1304
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A simple synthesis, involving a key coupling reaction, and the biological activity of the title compounds 16 and 17 are described. The key fragments are the amine·HCl salt 6 and the acids 9 and 13, which were smoothly coupled by using ethyl(dimethylaminopropyl)carbodiimide (EDCI) and 1- hydroxybenzotriazole (HOBt) in high yield. We have found that the in vitro growth inhibitory potency of the new compounds 16 and 17 exhibits good histone deacetylase (HDAC) activity. © 2008 Verlag der Zeitschrift für Naturforschung.
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의학전문대학원 > 의학과 > Journal papers
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