Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.contributor.author | 정재철 | * |
dc.date.accessioned | 2016-08-28T12:08:08Z | - |
dc.date.available | 2016-08-28T12:08:08Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 0932-0776 | * |
dc.identifier.other | OAK-5298 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220115 | - |
dc.description.abstract | A simple synthesis, involving a key coupling reaction, and the biological activity of the title compounds 16 and 17 are described. The key fragments are the amine·HCl salt 6 and the acids 9 and 13, which were smoothly coupled by using ethyl(dimethylaminopropyl)carbodiimide (EDCI) and 1- hydroxybenzotriazole (HOBt) in high yield. We have found that the in vitro growth inhibitory potency of the new compounds 16 and 17 exhibits good histone deacetylase (HDAC) activity. © 2008 Verlag der Zeitschrift für Naturforschung. | * |
dc.language | English | * |
dc.title | Convenient synthesis and evaluation of biological activity of benzyl (2S)-2-[(R)-1-hydroxy-2-oxo-(1-phenethyl)prop-3-ylcarbamoyl]-4-oxopiperidine- (or -4-oxopyrrolidine)-1-carboxylate as novel histone deacetylase inhibitors | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 63 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1300 | * |
dc.relation.lastpage | 1304 | * |
dc.relation.journaltitle | Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences | * |
dc.identifier.wosid | WOS:000262165600008 | * |
dc.identifier.scopusid | 2-s2.0-57749112870 | * |
dc.author.google | Oh S. | * |
dc.author.google | Moon H.-I. | * |
dc.author.google | Jung J.-C. | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.contributor.scopusid | 정재철(7402897187) | * |
dc.date.modifydate | 20240123112233 | * |