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dc.contributor.author정낙신-
dc.contributor.author최원준-
dc.date.accessioned2016-08-28T12:08:06Z-
dc.date.available2016-08-28T12:08:06Z-
dc.date.issued2008-
dc.identifier.issn0968-0896-
dc.identifier.otherOAK-5214-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/220097-
dc.description.abstractOn the basis of potent anti-HIV activity of 2',3'-dideoxynucleosides (ddNs), their bioisosteric analogues, 2',3'-dideoxy-4'-selenonucleosides (4'-seleno-ddNs) were first synthesized from a chiral template, d-glutamic acid using stereoselective ring-closure reaction of the dimesylate with Se2- and Pummerer type condensation of the selenoxide with nucleobases as key steps. X-ray crystallographic analysis indicated that 4'-seleno-ddNs adopted the same C2'-endo/C3'-exo (South) conformation as anti-HIV active ddNs, but did not show anti-HIV activity, indicating that RT seems to prefer the C2'-exo/C3'-endo (North) conformation on binding with their triphosphates. © 2008 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.titleDesign and synthesis of novel 2′,3′-dideoxy-4′-selenonucleosides as potential antiviral agents-
dc.typeArticle-
dc.relation.issue23-
dc.relation.volume16-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage9891-
dc.relation.lastpage9897-
dc.relation.journaltitleBioorganic and Medicinal Chemistry-
dc.identifier.doi10.1016/j.bmc.2008.10.034-
dc.identifier.wosidWOS:000260927000001-
dc.identifier.scopusid2-s2.0-55749104380-
dc.author.googleJeong L.S.-
dc.author.googleChoi Y.N.-
dc.author.googleTosh D.K.-
dc.author.googleChoi W.J.-
dc.author.googleKim H.O.-
dc.author.googleChoi J.-
dc.date.modifydate20160429000000-
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약학대학 > 약학과 > Journal papers
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