Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정낙신 | - |
dc.contributor.author | 최원준 | - |
dc.date.accessioned | 2016-08-28T12:08:06Z | - |
dc.date.available | 2016-08-28T12:08:06Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.other | OAK-5214 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220097 | - |
dc.description.abstract | On the basis of potent anti-HIV activity of 2',3'-dideoxynucleosides (ddNs), their bioisosteric analogues, 2',3'-dideoxy-4'-selenonucleosides (4'-seleno-ddNs) were first synthesized from a chiral template, d-glutamic acid using stereoselective ring-closure reaction of the dimesylate with Se2- and Pummerer type condensation of the selenoxide with nucleobases as key steps. X-ray crystallographic analysis indicated that 4'-seleno-ddNs adopted the same C2'-endo/C3'-exo (South) conformation as anti-HIV active ddNs, but did not show anti-HIV activity, indicating that RT seems to prefer the C2'-exo/C3'-endo (North) conformation on binding with their triphosphates. © 2008 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Design and synthesis of novel 2′,3′-dideoxy-4′-selenonucleosides as potential antiviral agents | - |
dc.type | Article | - |
dc.relation.issue | 23 | - |
dc.relation.volume | 16 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 9891 | - |
dc.relation.lastpage | 9897 | - |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | - |
dc.identifier.doi | 10.1016/j.bmc.2008.10.034 | - |
dc.identifier.wosid | WOS:000260927000001 | - |
dc.identifier.scopusid | 2-s2.0-55749104380 | - |
dc.author.google | Jeong L.S. | - |
dc.author.google | Choi Y.N. | - |
dc.author.google | Tosh D.K. | - |
dc.author.google | Choi W.J. | - |
dc.author.google | Kim H.O. | - |
dc.author.google | Choi J. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.contributor.scopusid | 최원준(55732412300;57211762651) | - |
dc.date.modifydate | 20230627112239 | - |