Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2016-08-28T12:08:06Z | - |
dc.date.available | 2016-08-28T12:08:06Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 0253-2964 | * |
dc.identifier.other | OAK-5201 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220095 | - |
dc.description.abstract | A series of new derivatives on the ring A of luotonin A were prepared by Friedländer condensation of 6,7,8,10-tetrahydropyrrolo[2,1-b]quinazoline-6, 10-dione and suitably substituted 2-aminobenzaldehydes and 2-aminoacetophenones. Their inhibitory activities on topoisomerases and cytotoxicities against selected human cancer cell lines were evaluated. Among the compounds tested, 8-fluoroluotonin A showed similar inhibitory activity on topoisomerase I comparable to camptothecin while luotonin A and 9-hydroxyluotonin A showed 1.37 and 0.94 times stronger inhibitory activity, respectively, on topoisomerase II compared to etoposide. Some derivatives of luotonin A showed moderate cytotoxicity. The possible relationship between the inhibitory activity on Topo II and the cytotoxicity of luotonin A and its analogues, thus, cannot be ruled out. | * |
dc.language | English | * |
dc.title | Synthesis and Biological Properties of Luotonin a Derivatives | * |
dc.type | Article | * |
dc.relation.issue | 10 | * |
dc.relation.volume | 29 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 1988 | * |
dc.relation.lastpage | 1992 | * |
dc.relation.journaltitle | Bulletin of the Korean Chemical Society | * |
dc.identifier.wosid | WOS:000260810500024 | * |
dc.identifier.scopusid | 2-s2.0-55249090178 | * |
dc.author.google | Rahman A.F.M.M. | * |
dc.author.google | Dong H.K. | * |
dc.author.google | Jing L.L. | * |
dc.author.google | Lee E.-S. | * |
dc.author.google | Na Y. | * |
dc.author.google | Jun K.-Y. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Jahng Y. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |