View : 158 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author오억수-
dc.contributor.author이정현-
dc.date.accessioned2016-08-28T12:08:05Z-
dc.date.available2016-08-28T12:08:05Z-
dc.date.issued2008-
dc.identifier.issn0171-9335-
dc.identifier.otherOAK-5171-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/220083-
dc.description.abstractSyndecan-4, a cell surface heparan sulfate proteoglycan, is known to regulate the organization of the cytoskeleton, and oligomerization is crucial for syndecan-4 function. We therefore explored a possible regulatory effect of syndecan-4 oligomerization on the cytoskeleton. Glutathione-S-transferase-syndecan-4 proteins were used to show that syndecan-4 interacted specifically with α-actinin, but not paxillin, talin, and vinculin. Interestingly, only dimeric, and not monomeric, recombinant syndecan-4 interacted with α-actinin in the presence of phosphatidylinositol 4,5-bisphosphate (PIP2), and PIP2 potentiated the interaction of both the cytoplasmic domain syndecan-4 peptide and recombinant syndecan-4 proteins with α-actinin, implying that oligomerization of syndecan-4 was important for this interaction. Consistent with this notion, α-actinin interaction was largely absent in syndecan-4 mutants defective in transmembrane domain-induced oligomerization, and α-actinin-associated focal adhesions were decreased in rat embryo fibroblasts expressing mutant syndecan-4. Besides, this interaction was consistently lower with the phosphorylation-mimicking syndecan-4 mutant S183E which is known to destabilize the oligomerization of the syndecan-4 cytoplasmic domain. Taken together, the data suggest that the oligomeric status of syndecan-4 plays a crucial role in regulating the interaction of syndecan-4 with α-actinin. © 2008 Elsevier GmbH. All rights reserved.-
dc.languageEnglish-
dc.titleThe oligomeric status of syndecan-4 regulates syndecan-4 interaction with α-actinin-
dc.typeArticle-
dc.relation.issue10-
dc.relation.volume87-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage807-
dc.relation.lastpage815-
dc.relation.journaltitleEuropean Journal of Cell Biology-
dc.identifier.doi10.1016/j.ejcb.2008.04.005-
dc.identifier.wosidWOS:000260585100005-
dc.identifier.scopusid2-s2.0-51249107328-
dc.author.googleChoi Y.-
dc.author.googleKim S.-
dc.author.googleLee J.-
dc.author.googleKo S.-g.-
dc.author.googleLee W.-
dc.author.googleHan I.-O.-
dc.author.googleWoods A.-
dc.author.googleOh E.-S.-
dc.contributor.scopusid오억수(7101967153)-
dc.date.modifydate20190901081003-
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE