Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정낙신 | - |
dc.contributor.author | 이상국 | - |
dc.contributor.author | 최원준 | - |
dc.date.accessioned | 2016-08-28T12:08:04Z | - |
dc.date.available | 2016-08-28T12:08:04Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.other | OAK-5134 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220078 | - |
dc.description.abstract | Novel D- and L-4′-thioadenosine derivatives lacking the 4′-hydroxymethyl moiety were synthesized, starting from D-mannose and D-gulonic γ-lactone, respectively, as potent and selective species-independent A3 adenosine receptor (AR) antagonists. Among the novel 4′-truncated 2-H nucleosides tested, a N6-(3- chlorobenzyl) derivative 7c was the most potent at the human A3 AR (Ki = 1.5 nM), but a N6-(3-bromobenzyl) derivative 7d showed the optimal species-independent binding affinity. © 2008 American Chemical Society. | - |
dc.language | English | - |
dc.title | Structure-activity relationships of truncated D- and L-4′- thioadenosine derivatives as species-independent A3 adenosine receptor antagonists | - |
dc.type | Article | - |
dc.relation.issue | 20 | - |
dc.relation.volume | 51 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 6609 | - |
dc.relation.lastpage | 6613 | - |
dc.relation.journaltitle | Journal of Medicinal Chemistry | - |
dc.identifier.doi | 10.1021/jm8008647 | - |
dc.identifier.wosid | WOS:000260102700038 | - |
dc.identifier.scopusid | 2-s2.0-54549084548 | - |
dc.author.google | Lak S.J. | - |
dc.author.google | Pal S. | - |
dc.author.google | Seung A.C. | - |
dc.author.google | Won J.C. | - |
dc.author.google | Jacobson K.A. | - |
dc.author.google | Gao Z.-G. | - |
dc.author.google | Klutz A.M. | - |
dc.author.google | Hou X. | - |
dc.author.google | Hea O.K. | - |
dc.author.google | Hyuk W.L. | - |
dc.author.google | Sang K.L. | - |
dc.author.google | Tosh D.K. | - |
dc.author.google | Hyung R.M. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.contributor.scopusid | 이상국(36067620500) | - |
dc.contributor.scopusid | 최원준(55732412300;57211762651) | - |
dc.date.modifydate | 20230627112239 | - |