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Synthesis of 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-hepatitis C virus (HCV) agents

Title
Synthesis of 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-hepatitis C virus (HCV) agents
Authors
Pei X.Choi W.J.Kim Y.M.Zhao L.X.Jeong L.S.
Ewha Authors
정낙신최원준
Issue Date
2008
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 31, no. 7, pp. 843 - 849
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
On the basis of potent anti-hepatitis C virus (HCV) activity of 2'-C-hydroxymethyladenosine, 3'-C-hydroxymethyl-substituted pyrimidine and purine nucleosides as potential anti-HCV agents were designed and synthesized from D-xylose via stereoselective Grignard reaction and conversion of the vinyl into hydroxymethyl group as key steps. © 2008 The Pharmaceutical Society of Korea.
DOI
10.1007/s12272-001-1236-z
Appears in Collections:
약학대학 > 약학과 > Journal papers
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