Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 황은숙 | * |
dc.date.accessioned | 2016-08-28T12:08:00Z | - |
dc.date.available | 2016-08-28T12:08:00Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 0022-1767 | * |
dc.identifier.other | OAK-4932 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220031 | - |
dc.description.abstract | Antitumor responses depend on type 1 immunity, which is severely impaired in mice deficient for the T-box expressed in T cells (T-bet) transcription factor. Both T-bet-deficient (T-betc) NK and CTL show defective function, which can be overcome by strong stimuli due to the expression of eomesodermin, another member of the T-box family. The effective response from T-bet -/- mice to viral infection and tumor initiation corroborates with these findings. However, T-bet -/- animals fail to control cancer metastasis and are, therefore, highly susceptible to tumor spread. The mechanism of T-bet-dcpendent resistance to metastatic disease is not known. In this study, we show that T-bet plays a role in inhibiting cancer metastasis by regulating the longevity and function of NK cells. Our data demonstrate that the absence of a proper innate immune response driven by NK cells in T-bet -/- mice precludes the initiation of a potent adaptive response to tumors. Adoptive transfer of wild-type activated NK cells protects T-bet -/- animals after melanoma challenge showing that reconstitution of the NK compartment in these mice is sufficient to mediate a significant reduction in tumor burden. Transfer of T-bet -/- A-NK cells fails to do so, due to their reduced in vivo survival, inefficient lysis of cancer cells, and poor IFN-γ production. Taken together, these results show for the first time an irreplaceable role for T-bet in the NK-mediated cross-talk between innate and adaptive immune responses to metastatic disease. Copyright © 2008 by The American Association of Immunologists, Inc. | * |
dc.language | English | * |
dc.title | T-bet plays a key role in NK-mediated control of melanoma metastatic disease | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 180 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 8004 | * |
dc.relation.lastpage | 8010 | * |
dc.relation.journaltitle | Journal of Immunology | * |
dc.identifier.wosid | WOS:000257404600024 | * |
dc.identifier.scopusid | 2-s2.0-50949108980 | * |
dc.author.google | Werneck M.B.F. | * |
dc.author.google | Lugo-Villarino G. | * |
dc.author.google | Hwang E.S. | * |
dc.author.google | Cantor H. | * |
dc.author.google | Glimcher L.H. | * |
dc.contributor.scopusid | 황은숙(8688011100) | * |
dc.date.modifydate | 20240123102458 | * |