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The use of an in vitro adenosine triphosphate-based chemotherapy response assay to predict chemotherapeutic response in breast cancer

Title
The use of an in vitro adenosine triphosphate-based chemotherapy response assay to predict chemotherapeutic response in breast cancer
Authors
Kim H.-A.Yom C.-K.Moon B.-I.Choe K.-J.Sung S.-H.Han W.-S.Choi H.-Y.Kim H.-K.Park H.-K.Choi S.-H.Yoon E.-J.Oh S.-Y.
Ewha Authors
한운섭성순희문병인
SCOPUS Author ID
한운섭scopusscopus; 성순희scopus; 문병인scopus
Issue Date
2008
Journal Title
Breast
ISSN
0960-9776JCR Link
Citation
vol. 17, no. 1, pp. 19 - 26
Indexed
SCIE; SCOPUS WOS scopus
Abstract
The adenosine triphosphate-based chemotherapy response assay (ATP-CRA) has the advantages of standardization, evaluability, reproducibility, and accuracy, and can be performed on relatively small numbers of tumor cells. A total of 43 patients were enrolled in the present study, and chemosensitivity tests were successfully performed in 40 (93.0%) of these patients. Twenty of the 40 received neoadjuvant chemotherapy or chemotherapy for metastatic breast cancer. The chemotherapy regimens used were doxorubicin plus docetaxel (n=9, 45.0%) or doxorubicin plus paclitaxel (n=11, 55.0%). Mean cell death rate, as determined by ATP-CRA, was lower in non-responders than in responders to therapy (P=0.012). Sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy for ATP-CRA were 78.6%, 100%, 100%, 66.7%, and 85.0%, respectively. Diagnostic accuracy achieved by immunohistochemistry using estrogen receptor or progesterone receptor was lower than that achieved using ATP-CRA. Expression of p53, erb-B2, Ki67, Bcl-2, Bcl-xL, and annexin I was not significantly associated with response to chemotherapy. Our results show that ATP-CRA has high specificity and positive predictive value for predicting response to chemotherapy. © 2007 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.breast.2007.06.001
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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