Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한운섭 | * |
dc.contributor.author | 성순희 | * |
dc.contributor.author | 문병인 | * |
dc.date.accessioned | 2016-08-28T12:08:59Z | - |
dc.date.available | 2016-08-28T12:08:59Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 0960-9776 | * |
dc.identifier.other | OAK-4915 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220027 | - |
dc.description.abstract | The adenosine triphosphate-based chemotherapy response assay (ATP-CRA) has the advantages of standardization, evaluability, reproducibility, and accuracy, and can be performed on relatively small numbers of tumor cells. A total of 43 patients were enrolled in the present study, and chemosensitivity tests were successfully performed in 40 (93.0%) of these patients. Twenty of the 40 received neoadjuvant chemotherapy or chemotherapy for metastatic breast cancer. The chemotherapy regimens used were doxorubicin plus docetaxel (n=9, 45.0%) or doxorubicin plus paclitaxel (n=11, 55.0%). Mean cell death rate, as determined by ATP-CRA, was lower in non-responders than in responders to therapy (P=0.012). Sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy for ATP-CRA were 78.6%, 100%, 100%, 66.7%, and 85.0%, respectively. Diagnostic accuracy achieved by immunohistochemistry using estrogen receptor or progesterone receptor was lower than that achieved using ATP-CRA. Expression of p53, erb-B2, Ki67, Bcl-2, Bcl-xL, and annexin I was not significantly associated with response to chemotherapy. Our results show that ATP-CRA has high specificity and positive predictive value for predicting response to chemotherapy. © 2007 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | The use of an in vitro adenosine triphosphate-based chemotherapy response assay to predict chemotherapeutic response in breast cancer | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 17 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 19 | * |
dc.relation.lastpage | 26 | * |
dc.relation.journaltitle | Breast | * |
dc.identifier.doi | 10.1016/j.breast.2007.06.001 | * |
dc.identifier.wosid | WOS:000257274300008 | * |
dc.identifier.scopusid | 2-s2.0-39049159199 | * |
dc.author.google | Kim H.-A. | * |
dc.author.google | Yom C.-K. | * |
dc.author.google | Moon B.-I. | * |
dc.author.google | Choe K.-J. | * |
dc.author.google | Sung S.-H. | * |
dc.author.google | Han W.-S. | * |
dc.author.google | Choi H.-Y. | * |
dc.author.google | Kim H.-K. | * |
dc.author.google | Park H.-K. | * |
dc.author.google | Choi S.-H. | * |
dc.author.google | Yoon E.-J. | * |
dc.author.google | Oh S.-Y. | * |
dc.contributor.scopusid | 한운섭(7401899962;24172227800) | * |
dc.contributor.scopusid | 성순희(7202731948;58455037400) | * |
dc.contributor.scopusid | 문병인(7101878644;56119062300) | * |
dc.date.modifydate | 20240118130118 | * |