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Genetic characteristics of 207 microsatellite markers in the Korean population and in other Asian populations

Title
Genetic characteristics of 207 microsatellite markers in the Korean population and in other Asian populations
Authors
Choi S.-J.Song H.-K.Jeong J.-H.Jeon I.-H.Yoon H.-S.Chung K.W.Won Y.-J.Choi J.-Y.Kim U.-K.
Ewha Authors
원용진
SCOPUS Author ID
원용진scopus
Issue Date
2008
Journal Title
Molecules and Cells
ISSN
1016-8478JCR Link
Citation
vol. 25, no. 2, pp. 301 - 304
Indexed
SCI; SCIE; SCOPUS; KCI WOS scopus
Abstract
Microsatellites, short tandem repeats, are useful markers for genetic analysis because of their high frequency of occurrence over the genome, high information content due to variable repeat lengths, and ease of typing. To establish a panel of microsatellite markers useful for genetic studies of the Korean population, the allele frequencies and heterozygosities of 207 microsatellite markers in 119 unrelated Korean, Indian and Pakistani individuals were compared. The average heterozygosity of the Korean population was 0.71, similar to that of the Indian and Pakistani populations. More than 80% of the markers showed heterozygosity of over 0.6 and were valuable as genetic markers for genome-wide screening for disease susceptibility loci in these populations. To identify the allelic distributions of the multilocus genetic data from these microsatellite markers, the population structures were assessed by clustering. These markers supported, with the most probability, three clustering groups corresponding to the three geographical populations. When we assumed only two hypothetical clusters (K), the Korean population was separate from the others, suggesting a relatively deep divergence of the Korean population. The present 207 microsatellite markers appear to reflect the historical and geographical origins of the different populations as well as displaying a similar degree of variation to that seen in previously published genetic data. Thus, these markers will be useful as a reference for human genetic studies on Asians. © KSMCB 2008.
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자연과학대학 > 생명과학전공 > Journal papers
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