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약학대학
약학과
Journal papers
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Synthesis of 3′-acetamidoadenosine derivatives as potential A 3 adenosine receptor agonists
Title
Synthesis of 3′-acetamidoadenosine derivatives as potential A 3 adenosine receptor agonists
Authors
Chun M.W.
;
Choi S.W.
;
Kang T.K.
;
Choi W.J.
;
Kim H.O.
;
Gao Z.-G.
;
Jacobson K.A.
;
Jeong L.S.
Ewha Authors
정낙신
;
최원준
SCOPUS Author ID
정낙신
; 최원준
Issue Date
2008
Journal Title
Nucleosides, Nucleotides and Nucleic Acids
ISSN
1525-7770
Citation
Nucleosides, Nucleotides and Nucleic Acids vol. 27, no. 4, pp. 408 - 420
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
On the basis of high binding affinity of 3′-aminoadenosine derivatives 2b at the human A3 adenosine receptor (AR), 3′- acetamidoadenosine derivatives 3a-e were synthesized from 1,2:5,6-di-O- isopropylidene-D-glucose via stereoselective hydroboration as a key step. Although all synthesized compounds were totally devoid of binding affinity at the human A3AR, our results revealed that 3′-position of adenosine can only be tolerated with small size of a hydrogen bonding donor like hydroxyl or amino group in the binding site of human A3AR. Copyright © Taylor & Francis Group, LLC.
DOI
10.1080/15257770801944436
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