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Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia

Title
Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia
Authors
Wu C.-Z.Cai X.F.Dat N.T.Hong S.S.Han A.-R.Seo E.-K.Hwang B.Y.Nan J.-X.Lee D.Lee J.J.
Ewha Authors
서은경한아름
SCOPUS Author ID
서은경scopus; 한아름scopusscopus
Issue Date
2007
Journal Title
Tetrahedron Letters
ISSN
0040-4039JCR Link
Citation
vol. 48, no. 50, pp. 8861 - 8864
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Two novel dimeric meroterpenoids, bisbakuchiols A and B, along with (S)-bakuchiol were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). Bisbakuchiols A and B contain an unprecedented dimeric meroterpenoid skeleton in which two meroterpenes are linked through a dioxane bridge. All compounds were evaluated for their potential to inhibit hypoxia-inducible factor-1 (HIF-1) activation induced by hypoxia in a HIF-1-mediated reporter gene assay in AGS human gastric cancer cells. (S)-Bakuchiol inhibited hypoxic activation of HIF-1 with an IC50 value of 6.1 μM. © 2007 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.tetlet.2007.10.059
Appears in Collections:
약학대학 > 약학과 > Journal papers
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