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Asymmetric synthesis and biological activity of l-bicyclocarba-d4T

Title
Asymmetric synthesis and biological activity of l-bicyclocarba-d4T
Authors
Moon H.R.Park A.-Y.Kim K.R.Chun M.W.Jeong L.S.
Ewha Authors
정낙신
Issue Date
2007
Journal Title
Nucleosides, Nucleotides and Nucleic Acids
ISSN
1525-7770JCR Link
Citation
vol. 26, no. 41559, pp. 1653 - 1657
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Novel l-bicyclocarba-d4T (1), an enantiomer of d-N-MCd4T has been enantiopurely synthesized as a potent anti-HIV agent starting from (R)-epichlorohydrin using tandem alkylation, chemoselective reduction of ester in the presence of lactone functional group, Grignard reaction, RCM reaction, and Mitsunobu reaction as key steps. l-N-MCd4T (1) was found to be very potent anti-HIV-1 (EC50 = 6.76 μg/mL) agent with no cytotoxicity. Copyright © Taylor & Francis Group, LLC.
DOI
10.1080/15257770701615599
Appears in Collections:
약학대학 > 약학과 > Journal papers
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