View : 100 Download: 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author손연수-
dc.contributor.author이화정-
dc.date.accessioned2017-08-28T11:37:17Z-
dc.date.available2017-08-28T11:37:17Z-
dc.date.issued2007-
dc.identifier.issn0162-0134-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/219928-
dc.description.abstractNovel cyclotriphosphazene-platinum(II) conjugates were prepared by hydrolysis and platination of the amphiphilic cyclotriphosphazenes grafted with equimolar hydrophilic methoxy-poly(ethylene glycol) (MPEG) and hydrophobic oligopeptide. These macromolecular conjugates were found to form stable nanoparticles with a mean diameter of approximately 90-200 nm depending on the hydrophobicity of the conjugated (diamine)platinum moieties. The nanoparticulate platinum(II) conjugates have shown temperature and concentration dependent particle sizes. However, the particle sizes of the conjugates were found to decrease to a certain size as the solution concentration was decreased but remained stable even at 10 μM, which is enough for systemic delivery by injection. The conjugates exhibited lower in vitro cytotoxicity than cisplatin but reasonably good activity against selected human tumor cell lines. © 2007 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.titleNanoparticulate platinum(II) anticancer drug: Synthesis and characterization of amphiphilic cyclotriphosphazene-platinum(II) conjugates-
dc.typeArticle-
dc.relation.issue41590-
dc.relation.volume101-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1931-
dc.relation.lastpage1936-
dc.relation.journaltitleJournal of Inorganic Biochemistry-
dc.identifier.doi10.1016/j.jinorgbio.2007.07.003-
dc.identifier.wosidWOS:000251523100047-
dc.identifier.scopusid2-s2.0-35348858137-
dc.author.googleYu J.Y.-
dc.author.googleJun Y.J.-
dc.author.googleJang S.H.-
dc.author.googleLee H.J.-
dc.author.googleSohn Y.S.-
dc.contributor.scopusid손연수(7201971323)-
dc.contributor.scopusid이화정(35069834100)-
dc.date.modifydate20180517105520-
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE