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dc.contributor.author오억수-
dc.contributor.author이정현-
dc.date.accessioned2016-08-28T12:08:49Z-
dc.date.available2016-08-28T12:08:49Z-
dc.date.issued2007-
dc.identifier.issn0006-291X-
dc.identifier.otherOAK-4452-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/219923-
dc.description.abstractFocal adhesion kinase (FAK) mediates signal transduction in response to multiple extracellular inputs, via tyrosine phosphorylation at specific residues. We recently reported that FAK Tyr-407 phosphorylation negatively regulates the enzymatic and biological activities of FAK, unlike phosphorylation of other tyrosine residues. In this study, we further investigated the effect of FAK Tyr-407 phosphorylation on cell transformation. We found that FAK Tyr-407 phosphorylation was lower in H-Ras transformed NIH3T3 and K-Ras transformed rat-2 fibroblasts than in the respective untransformed control cells. Consistently, FAK Tyr-407 phosphorylation was decreased in parallel with cell transformation in H-Ras-inducible NIH3T3 cells and increased during trichostatin A-induced detransformation of both K-Ras transformed rat-2 fibroblasts and H-Ras transformed NIH3T3 cells. In addition, overexpression of a phosphorylation-mimicking FAK Tyr-407 mutant inhibited morphological transformation of H-Ras-inducible NIH3T3 cells and inhibited invasion activity and anchorage-independent growth of H-Ras-transformed NIH3T3 cells. Taken together, these data strongly suggest that FAK Tyr-407 phosphorylation negatively regulates transformation of fibroblasts. © 2007 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.titlePhosphorylation of focal adhesion kinase at Tyrosine 407 negatively regulates Ras transformation of fibroblasts-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume364-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1062-
dc.relation.lastpage1066-
dc.relation.journaltitleBiochemical and Biophysical Research Communications-
dc.identifier.doi10.1016/j.bbrc.2007.10.134-
dc.identifier.wosidWOS:000251358500057-
dc.identifier.scopusid2-s2.0-36048974618-
dc.author.googleJeon J.-
dc.author.googleLee H.-
dc.author.googlePark H.-
dc.author.googleLee J.-h.-
dc.author.googleChoi S.-
dc.author.googleHwang J.-
dc.author.googleHan I.-O.-
dc.author.googleOh E.-S.-
dc.contributor.scopusid오억수(7101967153)-
dc.date.modifydate20190901081003-
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자연과학대학 > 생명과학전공 > Journal papers
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