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A new flavanone glycoside from the dried immature fruits of Poncirus trifoliata

Title
A new flavanone glycoside from the dried immature fruits of Poncirus trifoliata
Authors
Han A.-R.Kim J.-B.Lee J.Nam J.-W.Lee I.-S.Shim C.-K.Lee K.-T.Seo E.-K.
Ewha Authors
서은경한아름
SCOPUS Author ID
서은경scopus; 한아름scopusscopus
Issue Date
2007
Journal Title
Chemical and Pharmaceutical Bulletin
ISSN
0009-2363JCR Link
Citation
vol. 55, no. 8, pp. 1270 - 1273
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A new flavanone glycoside, (2R)-5-hydroxy-4′-methoxyflavanone-7-O- {β-glucopyranosyl-(1→2)-β-glucopyranoside} (1), was isolated from the EtOAc extract of dried immature fruit of Poncirus trifoliata, together with three known compounds, (2S)-poncirin (2), (2S)-naringin (3), and (2S)-poncirenin (4). The structure of compound 1 was elucidated by spectroscopic data analysis, including 1D and 2D NMR experiments. Among the isolates, compound 2 exhibited considerable inhibitory activity against lipopolysaccharide (LPS)-induced prostaglandin E2 (PGE2) and interleukin-6 (IL-6) production, and mRNA expression in RAW 264.7 murine macrophage cells. © 2007 Pharmaceutical Society of Japan.
DOI
10.1248/cpb.55.1270
Appears in Collections:
약학대학 > 약학과 > Journal papers
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