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Design, synthesis, and molecular modeling studies of 5′-deoxy-5′-ureidoadenosine: 5′-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase

Title
Design, synthesis, and molecular modeling studies of 5′-deoxy-5′-ureidoadenosine: 5′-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase
Authors
Wang T.Lee H.J.Tosh D.K.Kim H.O.Pal S.Choi S.Lee Y.Moon H.R.Zhao L.X.Lee K.M.Jeong L.S.
Ewha Authors
이강만정낙신최선
SCOPUS Author ID
이강만scopus; 최선scopus
Issue Date
2007
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 17, no. 16, pp. 4456 - 4459
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
5′-Deoxy-5′-ureidoadenosine was designed and synthesized as a potent inhibitor of S-adenosylhomocysteine hydrolase (SAH), in which 5′-ureido group acted as multiple hydrogen bonding donor in binding with active site residues of SAH in the molecular modeling study. © 2007.
DOI
10.1016/j.bmcl.2007.06.013
Appears in Collections:
약학대학 > 약학과 > Journal papers
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