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TRAF1 and its biological functions

Title
TRAF1 and its biological functions
Authors
Lee S.Y.Choi Y.
Ewha Authors
이수영
SCOPUS Author ID
이수영scopus
Issue Date
2007
Journal Title
Advances in Experimental Medicine and Biology
ISSN
0065-2598JCR Link
Citation
vol. 597, pp. 25 - 31
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Tumor necrosis factor (TNF) receptor-associated factor (TRAF)1 was originally identified based on its ability to interact with the cytosolic domain of TNF receptor type 2 (TNFR2). TRAF1 is unique among TRAF proteins in that it lacks RING domain found in the N-terminal regions of other TRAFs. TRAF1 can associate with multiple TNFR family members and can also bind several protein kinases and adaptor proteins suggesting that this protein likely possesses multiple functions in cytokine signaling networks. Although our understanding of TRAF1 functions and the underlying mechanisms at molecular and cellular levels has been advanced in recent years, much still needs to be learned before we have a full grasp of TRAF1 biology. © 2007 Landes Bioscience and Springer Science+Business Media, LLC.
DOI
10.1007/978-0-387-70630-6-2
ISBN
9780387706290
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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