View : 231 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author손연수-
dc.contributor.author이화정-
dc.date.accessioned2016-08-28T12:08:42Z-
dc.date.available2016-08-28T12:08:42Z-
dc.date.issued2007-
dc.identifier.issn0960-894X-
dc.identifier.otherOAK-4050-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/219862-
dc.description.abstractIn order to develop a new gene delivery vector, a novel cationic poly(organophosphazene) was synthesized by stepwise nucleophilic substitutions of poly(dichlorophosphazene) with a hydrophilic methoxy-poly(ethylene glycol) (MPEG) as a shielding group and a branched tetra(l-lysine), LysLys(LysEt)2, as a cationic moiety. The cationic polymer has shown to form a polyplex by DNA condensation and very low in vitro cytotoxicity probably due to the shielding effect of MPEG, which provides a basis for improving the low gene transfection yield of cationic polyphosphazenes. © 2007 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.titleA tetra(l-lysine)-grafted poly(organophosphazene) for gene delivery-
dc.typeArticle-
dc.relation.issue11-
dc.relation.volume17-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage2975-
dc.relation.lastpage2978-
dc.relation.journaltitleBioorganic and Medicinal Chemistry Letters-
dc.identifier.doi10.1016/j.bmcl.2007.03.069-
dc.identifier.wosidWOS:000247052900003-
dc.identifier.scopusid2-s2.0-34247871415-
dc.author.googleJun Y.J.-
dc.author.googleKim J.H.-
dc.author.googleChoi S.J.-
dc.author.googleLee H.J.-
dc.author.googleJun M.J.-
dc.author.googleSohn Y.S.-
dc.contributor.scopusid손연수(7201971323)-
dc.contributor.scopusid이화정(35069834100)-
dc.date.modifydate20180517105520-
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE