DSpace at EWHA: A tetra(l-lysine)-grafted poly(organophosphazene) for gene delivery

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DC Field	Value	Language
dc.contributor.author	손연수	*
dc.contributor.author	이화정	*
dc.date.accessioned	2016-08-28T12:08:42Z	-
dc.date.available	2016-08-28T12:08:42Z	-
dc.date.issued	2007	*
dc.identifier.issn	0960-894X	*
dc.identifier.other	OAK-4050	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/219862	-
dc.description.abstract	In order to develop a new gene delivery vector, a novel cationic poly(organophosphazene) was synthesized by stepwise nucleophilic substitutions of poly(dichlorophosphazene) with a hydrophilic methoxy-poly(ethylene glycol) (MPEG) as a shielding group and a branched tetra(l-lysine), LysLys(LysEt)2, as a cationic moiety. The cationic polymer has shown to form a polyplex by DNA condensation and very low in vitro cytotoxicity probably due to the shielding effect of MPEG, which provides a basis for improving the low gene transfection yield of cationic polyphosphazenes. © 2007 Elsevier Ltd. All rights reserved.	*
dc.language	English	*
dc.title	A tetra(l-lysine)-grafted poly(organophosphazene) for gene delivery	*
dc.type	Article	*
dc.relation.issue	11	*
dc.relation.volume	17	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	2975	*
dc.relation.lastpage	2978	*
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry Letters	*
dc.identifier.doi	10.1016/j.bmcl.2007.03.069	*
dc.identifier.wosid	WOS:000247052900003	*
dc.identifier.scopusid	2-s2.0-34247871415	*
dc.author.google	Jun Y.J.	*
dc.author.google	Kim J.H.	*
dc.author.google	Choi S.J.	*
dc.author.google	Lee H.J.	*
dc.author.google	Jun M.J.	*
dc.author.google	Sohn Y.S.	*
dc.contributor.scopusid	손연수(7201971323)	*
dc.contributor.scopusid	이화정(57102029300)	*
dc.date.modifydate	20240118154655	*